Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey
نویسندگان
چکیده
AIMS The purpose of this study was to determine the prevalence of nasopharyngeal carriage of Streptococcus pneumoniae in healthy children aged 0-6 years who were vaccinated with pneumococcal conjugate vaccine. METHODS The cross-sectional study was conducted on 150 healthy Turkish children aged between 1 month and 6 years of age. Serotyping was performed and risk factors of carriage were evaluated. RESULTS The overall carriage rate was 14%. Vaccine type serotypes were determined in 17 (12.6%) children received full dose vaccinated pneumococcal conjugate vaccine 13. The highest carriage rate was observed among children younger than 24 months with 76.2%. The risk factors such as respiratory infection in the last months, age, attendance daycare center, and antibiotic usage were not found for the carriage compared with the multivariate analysis. Overall S. pneumoniae strains were considered as penicillin susceptible and antimicrobial resistance was limited. CONCLUSION We observed low rate of pneumococcal carriage in children after pneumococcal conjugate vaccine 13 implementation compared to children receiving pneumococcal conjugate vaccine 7. Although reduction of vaccine serotypes colonization in pneumococcal conjugate vaccine 13 vaccinated children was observed, it continues.
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